Is it better to use "use only" when using module?

In my fortran program, there are hundreds of global variables, and they are all stored in a single module file. Then, I also have ~50 subroutines, each of which uses only some of the global variables. In this case, is there any compiling or simulation speed difference between (1) using "only" to select some of the global variables in each subroutine and (2) just using all global variables in every subroutine.

 For example:

If I have a module file:
   module mod_global
   ...
   real :: num1, num2, num3, ..., num1000
   ...
   end module

First approach:
   subroutine_1
   use mod_global, only : num1, num2, num3, ..., num100
   ...
   end subroutine_1

   subroutine_2
   use mod_global, only : num101, ..., num200
   ...
   end subroutine_2 

Second approach:  
   subroutine_1
   use mod_global
   ...
   end subroutine_1

   subroutine_2
   use mod_global
   ...
   end subroutine_2 

I know that it is better to control (manage) if I use "use, only" combination. However, I want to know whether there is a speed difference (both in compilation and execution) between the two approaches.